Pentadecapeptide
Healing & Recovery PeptideresearchAlso known as: BPC-157 Arginate, BPC-157 Arg Salt, Pentadecapeptide BPC 157
The arginine salt form of BPC-157, optimized for oral bioavailability and stability, used interchangeably with BPC-157 for tissue healing and gut repair.
Overview
Pentadecapeptide refers specifically to the arginine salt formulation of BPC-157 (Body Protection Compound-157), often designated BPC-157 Arginate or BPC 157 arginine salt. While chemically the same core 15-amino acid peptide as BPC-157, the arginine salt form enhances stability and solubility, particularly for oral administration. This formulation is the version most commonly referenced in research studies and is considered the pharmaceutical-grade standard. The term 'pentadecapeptide' literally means 'fifteen amino acid peptide' and is used in scientific literature to describe BPC-157 in its most studied salt form. Its therapeutic profile mirrors BPC-157: promoting healing of tendons, ligaments, muscles, GI tissue, and modulating the nitric oxide and growth factor systems.
Mechanism of Action
Identical to BPC-157: (1) Upregulates VEGF, EGF, and FGF growth factor receptors to promote angiogenesis and tissue repair; (2) Modulates the nitric oxide system for vasodilation and enhanced blood flow; (3) Promotes collagen and reticulin formation for connective tissue repair; (4) Interacts with dopaminergic and GABAergic systems for neuroprotective effects; (5) Counteracts GI damage from NSAIDs and alcohol; (6) Activates the FAK-paxillin pathway for cell migration. The arginine salt form improves dissolution and may enhance oral bioavailability.
Molecular Formula
C62H98N16O22 (free peptide) + C6H14N4O2 (arginine)
Molecular Weight
~1593 g/mol (arginine salt)
Sequence
Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val (arginine salt form)
Dosage Protocols
Dose Range
250mcg – 500mcg
Frequency
Twice daily
Route
oral
Cycle Length
6-12 weeks
The arginine salt form is specifically preferred for oral use due to enhanced stability in gastric acid. Take on an empty stomach for best absorption.
Source: Preclinical studies and clinical protocols
Side Effects
| Effect | Severity |
|---|---|
| Injection site redness | mild |
| Nausea | mild |
| Dizziness | mild |
| Headache | mild |
Pros & Cons
Arginine salt form provides improved stability and solubility compared to acetate form
Optimized for oral bioavailability, making it the preferred form for gut healing protocols
Same extensive preclinical evidence base as BPC-157 across multiple tissue types
Extremely favorable safety profile with minimal side effects
Functionally identical to BPC-157 — not a distinct peptide, which may cause confusion
Same limitation as BPC-157: lacks human randomized controlled trials
Not FDA-approved with uncertain regulatory status
Supplier quality varies; purity verification important
Research Studies
Legal Status
Not FDA-approved. Available as a research chemical. Same regulatory status as BPC-157. Banned by WADA for competitive athletes.
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