Matrixyl
Cosmeceutical / Signal Peptidecommercial (cosmetic ingredient)Also known as: Palmitoyl Pentapeptide-4, Pal-KTTKS, Matrixyl 3000
A lipopeptide used in cosmetic skincare that stimulates collagen and extracellular matrix production, often marketed as a non-invasive alternative to retinol for anti-wrinkle treatment.
Overview
Matrixyl (palmitoyl pentapeptide-4) is a synthetic signal peptide consisting of five amino acids (KTTKS) linked to a palmitic acid chain to enhance skin penetration. It was developed by Sederma (now part of Croda) and is one of the most commercially successful cosmeceutical peptides worldwide. The KTTKS sequence is a fragment of type I procollagen that acts as a matrikine — a peptide fragment released during extracellular matrix turnover that signals cells to produce new matrix components. When applied topically, Matrixyl stimulates fibroblasts to increase production of collagen types I, III, and IV, as well as fibronectin and other extracellular matrix proteins. Clinical studies have demonstrated measurable wrinkle reduction comparable to retinol but with better tolerability. Matrixyl 3000 is an enhanced version that combines palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7 for synergistic effects.
Mechanism of Action
Matrixyl acts through matrikine signaling: (1) The KTTKS sequence mimics collagen breakdown fragments, triggering a wound-repair-like response in fibroblasts; (2) Activates TGF-β signaling pathway, upregulating collagen synthesis; (3) Stimulates production of collagens I, III, IV, and glycosaminoglycans; (4) Promotes fibronectin synthesis, improving skin structural integrity; (5) The palmitoyl chain facilitates penetration through the stratum corneum lipid barrier; (6) Modulates matrix metalloproteinase (MMP) activity to balance collagen production and degradation.
Molecular Formula
C39H75N5O7
Molecular Weight
711.56 g/mol
Sequence
Pal-Lys-Thr-Thr-Lys-Ser
Dosage Protocols
Dose Range
2% concentration – 10% concentration
Frequency
Twice daily
Route
topical
Cycle Length
Ongoing — best results seen after 8-12 weeks of consistent use
Apply to clean skin before moisturizer. Can be combined with hyaluronic acid, vitamin C, and other peptides. Most commercial products contain 2-5%. Best applied morning and evening.
Source: Manufacturer guidelines and clinical studies
Side Effects
| Effect | Severity |
|---|---|
| Mild skin irritation | mild |
| Redness at application site | mild |
| Allergic contact dermatitis | moderate |
Pros & Cons
Clinically proven to reduce wrinkle depth and volume with consistent topical use
Excellent tolerability — far fewer side effects than retinoids or acids
Widely available in commercial skincare products at various price points
Can be combined with most other skincare actives including retinol, vitamin C, and hyaluronic acid
Results are subtle and require consistent use for 2-3 months before visible improvement
Less potent than injectable treatments (Botox, fillers) or prescription retinoids
Penetration through intact skin is limited despite the palmitoyl chain
Many commercial products contain very low concentrations that may be insufficient for efficacy
Research Studies
Legal Status
Widely available as a cosmetic ingredient. Not classified as a drug. No prescription required. Included in numerous over-the-counter skincare products globally.
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